Clinical Trials & Research

Clinical research is an important component of the Center’s mission. Our clinical and laboratory staffs have initiated several research studies to answer many clinical questions. These studies help expand the scientific knowledge base and provide new technology to patients. Our clinical findings have been published in national journals and have played a role in advancing new knowledge to other Reproductive Medicine practices throughout the country. We are able to conduct this research only through the cooperation of our patients who are willing to participate in these studies. We dedicate all this advanced reproduction knowledge to them.

Current Research Being Done at the Center

We currently have 3 exciting research projects taking place at the Center:

Eeva MERGE Study–MultiCenter Registry with Eeva (Early Embryo Viability Assessment Test)

This is a new study that is just beginning.  We now have to ability to view embryo development under the microscope without having to remove the embryos from the incubator.  The Eeva system takes a photo every 5 minutes and compiles a video of embryo development.  The purpose of this study is to collect data to compare two different techniques for viewing embryos during IVF treatment, standard techniques versus the Eeva SystemTM.  The Early Embryo Viability Assessment (Eeva) test was developed to be used in IVF laboratories to aid embryologists in selecting the best embryo for transfer.  Eligible participants include women undergoing fresh in vitro fertilization (using their own eggs or donor eggs) who do not have a history of cancer.  Gestational carriers are not eligible.  Participation in the study is voluntary and those enrolled will be provided with Eeva at no additional cost.  Participants will not receive financial compensation for their enrollment.  The Center hopes to enroll 100 women to participate in this observational study.  If you are interested in learning more, please discuss the Eeva study with your CARS IVF clinical staff.

Dual Trigger Study

You are invited to take part in this study because you are about to undergo and IVF cycle and deemed to be at risk for Ovarian hyperstimulation syndrome, (OHSS) development. The purpose of this study is to compare pregnancy rates and differences in OHSS development in IVF patients who receive low dose hCG at the time of Lupron trigger to those who receive low dose hCG after Lupron trigger, at the time of egg retrieval.  Ovarian hyperstimulation syndrome, OHSS, is a complication of in vitro fertilization caused by treatment with some fertility drugs.  When human chorionic gonadotropin, hCG, is given as the trigger in IVF treatments, it can lead to the development of OHSS.  The use of another fertility drug, Lupron, as the IVF trigger, prevents OHSS from developing, but may also lead to a reduction in pregnancy rates.  This study attempts to evaluate whether administration of hCG in conjunction with a Lupron trigger can be used to improve pregnancy outcomes while minimizing the risk of developing OHSS.  Dual Trigger is a double-blind study and enrolled participants will be placed randomly into one of two groups.  Participants will not receive financial compensation, however, some of the medications required for the IVF cycle will be provided free of charge.  Participation is voluntary, and enrolled patients can choose to withdraw from the study at any time.  The Center hopes to enroll a total of 80 participants for the Dual Trigger study.  For eligibility requirements or any additional information, please feel free to contact CARS clinical staff or the research coordinator at the number listed below.

Endometrial Biopsy Microarray Study

You are invited to take part in this study because you are a healthy young women who will undergo an IVF cycle for the purpose of donating your eggs to another couple.  The purpose of this study is to evaluate possible differences in the way certain genes are produced that may affect the lining of the uterus causing lower pregnancy rates, following the use of Lupron versus hCG for egg maturation in women undergoing controlled ovarian hyperstimulation (COH. Enrollment in the study is voluntary.  Participants will receive financial compensation.  For more information, please consult your CARS clinician.

If you are interested in more information on these research projects or wish to discuss eligibility for participation, please contact your physician here at the Center or Dr. Evelyn Neuber, Clinical Research Coordinator at 860 679-4612.